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Numbrino For Sale

$1,599.00

Numbrino For Sale

The recommended dose of Numbrino ranges from 40 mg to 160 mg, depending on the nasal mucosal area to be anesthetized and the procedure to be performed. Each pledget absorbs one mL of Numbrino nasal solution. A maximum of two soaked cotton or rayon pledgets may be placed in each nasal cavity, for a total dose of 160 mg for Numbrino nasal solution 4%.

Numbrino For Sale

Numbrino (cocaine hydrochloride) is for intranasal use only. 2. Do not apply Numbrino to damaged nasal mucosa. 3. Unless the FDA has determined that these products can be substituted, do not substitute Numbrino for other intranasal cocaine products because this may result in different local and/or systemic exposures.

The recommended dose of Numbrino ranges from 40 mg to 160 mg, depending on the nasal mucosal area to be anesthetized and the procedure to be performed. Each pledget absorbs one mL of Numbrino nasal solution. A maximum of two soaked cotton or rayon pledgets may be placed in each nasal cavity, for a total dose of 160 mg for Numbrino nasal solution 4%. The total dose for any one procedure or surgery should not exceed 3 mg/kg cocaine hydrochloride.

 

Indications and Usage for Numbrino

Numbrino (cocaine hydrochloride) nasal solution is indicated for the induction of local anesthesia of the mucous membranes when performing diagnostic procedures and surgeries on or through the nasal cavities in adults.

Numbrino Dosage and Administration

Important Dosage and Administration Instructions

Numbrino (cocaine hydrochloride) is for intranasal use only.

Do not apply Numbrino to damaged nasal mucosa.

Unless the FDA has determined that these products can be substituted, do not substitute Numbrino for other intranasal cocaine products because this may result in different local and/or systemic exposures.

Dosing Recommendations

The recommended dose of Numbrino ranges from 40 mg to 160 mg, depending on the nasal mucosal area to be anesthetized and the procedure to be performed. Each pledget absorbs one mL of Numbrino nasal solution. A maximum of two soaked cotton or rayon pledgets may be placed in each nasal cavity, for a total dose of 160 mg for Numbrino nasal solution 4%.

The total dose for any one procedure or surgery should not exceed 3 mg/kg cocaine hydrochloride.

The recommended size of the cotton or rayon pledgets for use with Numbrino measure ½ inch x 3 inch (sold separately).

 

Preparation and Administration of Numbrino via Pledgets

Draw up 4 mL Numbrino into a syringe calibrated in mL. Stack four pledgets and apply 2 mL of solution to the top of the stacked pledgets. Turn the stacked pledgets over and apply 2 mL of solution to the other side. Numbrino should be evenly distributed on all pledgets.

Following Numbrino application to pledgets, place One (1) or two (2) pledgets in each nasal cavity, for a maximum of 2 pledgets used per nostril.

Leave pledgets in place for up to 20 minutes. Remove pledgets and continue with the procedure. Discard pledgets, and dispose of any unused pledgets and remaining solution in accordance with institutional procedures for CII products.

Pledgets should be removed immediately upon any sign or symptom of an adverse event.

Dosage Forms and Strengths

Numbrino (cocaine hydrochloride) nasal solution is a clear, blue-green solution provided in a concentration of 4% (40 mg/mL). The 4% nasal solution is provided in both a single-use 4 mL (160 mg/4 mL) and multiple-use 10 ml (400 mg/10 mL) bottles. Each 1 mL of the 4% solution contains 40 mg of cocaine hydrochloride, equivalent to 35.7 mg of cocaine free base as aqueous solution, for topical nasal administration.

 

Contraindications

Numbrino is contraindicated in: patients with a known history of hypersensitivity to cocaine hydrochloride, other ester-based local anesthetics, or any other component of the nasal solution [see Warnings and Precautions (5.5)].

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